Scleroderma or Systemic Sclerosis is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. The symptoms vary greatly and can range from very mild to life threatening. The seriousness will depend on the parts of the body affected and the extent to which they are affected.

| Aetna | Not specifically mentioned |
| Aflac | Not specifically mentioned |
| Americo | May be eligible for Select 1 or Select 2 |
| Living Promise | Decline if diagnosed with, treated for or taken medications for in last 4 years |
| Royal Neighbors | Not specifically mentioned |
| Corebridge | Decline if diagnosed with, treated for or taken medication for in the last 48 months |
| TransAmerica | Not specifically mentioned |
| Prudential | Not specifically mentioned |
| GTL | Not specifically mentioned |