Systemic Lupus is an autoimmune disease. In this disease, the immune system mistakenly attacks healthy tissue. It can affect skin, joints, kidneys, brain, and other organs.

| Aetna | OK for Standard |
| Aflac | OK for Standard |
| Americo | Decline |
| Living Promise | Decline |
| Royal Neighbors | Decline |
| Corebridge | Decline if diagnosed or treated in the last 48 months |
| TransAmerica | Allowed |
| Prudential | Decline for Preferred if ever diagnosed, treated or advised to receive treatment |
| GTL | Not specifically mentioned |
*TruStage TAWL product has no auto decline conditions