Multiple Sclerosis is a chronic disease that affects the central nervous system, especially the brain, spinal chord, and optic nerves.

| Aetna | OK for Standard |
| Aflac | OK for Standard |
| Americo | Decline |
| Living Promise | Decline if diagnosed with, treated for or taken medications for in the last 4 years. |
| Royal Neighbors | Allowed |
| Corebridge | Decline |
| TransAmerica | Allowed |
| Prudential | Decline for Preferred if ever diagnosed, treated or advised to receive treatment |
| GTL | Not specifically mentioned |